The Blues managed to scrape past the top-flight relegation battlers to secure a crucial three points at Brammall Lane.
With the broadcaster averaging 1.5m viewers per game, it was a big clash of the weekend - but “up to 100,000 were let down.
The charity Colour Blind Awareness have previously stated that one in 12 men - or six per-cent - are affected by the visual impairment.
As Sheffield’s red-and-white kit clashed with the visitors’ “arctic blue”, it left some viewers venting their anger on Twitter.
“What a ridiculous, unnecessary kit choice from Chelsea tonight,” one supporter said.
Another commented: “Someone with a bigger brain has got to explain how this is easier to see than Chelsea playing in their home blue kit?”
While a third had a ruthless response, with: “I turned it on, saw 20 matching shirts and simply turned it off again.”
And a fourth sarcastically added: “Well done, Chelsea - you really needed your almost-white away kit for this fixture.”
All Premier League kit requests are put through an “online software tool” before the match to make sure they are “colour blind friendly”.
But Chelsea’s win over Sheffield was the fifth time this season that kits have clashed - despite huge volumes of guidance from the FA, UEFA and top-flight.
And the charity explained that both teams would have been made aware of the clash for colour blind viewers and decided to to take action.
“There is software that should have highlighted this,' said Kathryn Albany-Ward, the chief executive of Colour Blind Awareness.
“When the Premier League receive the kit choices from the clubs they run the software and highlight if it could be a kit clash. Then it's up to the clubs to decide.
“There must be a reason Chelsea are playing in the away kit.
“They have decided they know better. That is my interpretation from what has happened before.
“It is the club's decision to override the Premier League administrators, if that's what they want to do.”